Comparative Chemical Characterization and in Vitro Antimicrobial Evaluation of Essential Oils from Species of the Genus Senecio From Patagonia, Argentina
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Abstract
Species of the genus Senecio have the largest medicinal value for the native Patagonian communities, and studies on the biological activities attributed to them are scarce.This article reports on the chemical composition of four species from genus Senecio. Senecio mustersii var.mustersii Senecio subpanduratus O.Hoffm. Senecio filaginoides De Candolle and Senecio coluhuapiensis Spegazzini respectively, from Patagonia Argentina and the evaluation of its antibacterial activity. Essential oils were obtained by hydrodistillation from fresh leaves of all species and were analyzed by GC-MS. In the essential oils from the leaves of the four species, a total of 24 compounds were identified in S. mustersii, 21 in S. subpanduratus, 25 in S. filaginoides, and 28 in S. coluhuapiensis. These compounds collectively accounted for more than 95.2%, 92.9%, 93.5%, and 94.2% of the total oil composition, respectively. The major constituents were α-pinene (53.3 %) in S.mustersii, sabinene (23.8 %) in S.subpanduratus and Terpinen-4-ol (19.6%) in S.coluhuapiensis. In all analysis it was observed that essential oil from S.filaginoides have (53.7 %) of a compound called 8-hydroxy-9-keto-10αH- eremophil-7(11)-en-8,12-olide. The essential oils of S.mutersii, S. subpanduratus, S.filaginoides and S.coluhuapiensis showed antimicrobial activity against Staphylococcus aureus with (MIC 3.9 μg/mL). The essential oils of S. subpanduratus and S.filaginoides showed antimicrobial activity against Candida albicans (MIC 1.9 μg/mL). The essential oils of S.filaginoides and S.coluhuapiensis showed antimicrobial activity against Candida guillermondi (MIC 1.9 μg/mL).
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