Hematologic Parameters, Oxidative Markers, and Histopathological Effects of Artocarpus Heterophyllus on Lead-Induced Mice

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Published: Nov 6, 2025
DOI: https://doi.org/10.47191/ijpbms/v5-i11-01
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Bohr Lete Edward
Department Of Human Physiology, Rivers State University, Port Harcourt, Nigeria
Owhorji Bright
Department Of Human Physiology, Rivers State University, Port Harcourt, Nigeria
G. P. Onyeso
Department Of Human Physiology, Rivers State University, Port Harcourt, Nigeria
Ekweme Bestman
Department Of Human Physiology, Rivers State University, Port Harcourt, Nigeria

Abstract

Lead toxicity is a significant environmental and health concern, causing oxidative stress and hematologic alterations. This study investigates the potential protective effects of Artocarpus heterophyllus (AH) against lead-induced hematologic and oxidative damage in mice. Mice were divided into seven groups and exposed to lead acetate, with different groups receiving various parts of AH (seed, fruit, leaf, bark). Hematologic parameters, oxidative stress markers, and histopathology of vital organs were analyzed. The results showed that AH mitigated lead-induced alterations by improving antioxidant enzyme activities and restoring hematologic indices. These findings suggest AH as a potential therapeutic agent for lead toxicity.

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How to Cite
Lete Edward, B. ., Bright, O. ., Onyeso, G. P. ., & Bestman, E. . (2025). Hematologic Parameters, Oxidative Markers, and Histopathological Effects of Artocarpus Heterophyllus on Lead-Induced Mice. International Journal of Pharmaceutical and Bio Medical Science, 5(11), 574–577. https://doi.org/10.47191/ijpbms/v5-i11-01
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Vol. 5 No. 11 (2025): Volume 05 Issue 11 November 2025
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

References

I. Flora, G., Gupta, D., & Tiwari, A. (2012). Lead exposure: Health effects, mechanisms, and toxicity. Medicina, 48(2), 85-98.

II. Gidlow, D. A. (2015). Lead toxicity: An overview. Occupational Medicine, 65(5), 348-356.

III. Patrick, L. (2006). Lead toxicity: A review of the literature. Alternative Medicine Review, 11(2), 114-127.

IV. Singh, D. P., Belwal, T., & Devkota, H. P. (2015). Phytochemistry of Artocarpus heterophyllus. Journal of Functional Foods, 18, 891-904.

V. Rahman, M. A., et al. (2018). Protective effects of Artocarpus heterophyllus against oxidative stress. Journal of Medicinal Plants Research, 12(4), 245-252.