Effect of Hydromethanolic Mangifera Indica Stem Bark and Leaf Extracts on Motor Coordination and Grip Strength in ECT-Induced Seizure in Male Wistar Rats
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Abstract
Electroconvulsive therapy (ECT), although clinically effective in treatment-resistant depression, is often associated with adverse neurocognitive effects, particularly impairments in learning and memory. The search for safe adjunctive therapies has drawn attention to plant-derived neuroprotectants. This study investigated the effect of hydromethanolic extracts of Mangifera indica stem bark (MSBE) and leaf (MLE) on learning and memory in ECT-induced seizure models in male Wistar rats, using beam walk and forelimb grip tests. Rats were divided into eight groups: control, ECT-only, ECT + diazepam (DZP), MSBE (300 and 600 mg/kg), and MLE (300 and 600 mg/kg). ECT markedly impaired motor coordination and grip performance, reflected in prolonged beam walk latency (Week 4: 265.00 ± 62.85 s vs. control: 53.70 ± 21.73 s, p<0.05) and reduced grip strength. Treatment with MSBE and MLE significantly attenuated these deficits, with MLE (600 mg/kg) showing the most robust effects, improving grip strength (Week 4: 28.20 ± 0.86 vs. ECT: 7.10 ± 2.07, p<0.05) and reducing beam walk latency (Week 4: 15.50 ± 6.37 s vs. ECT: 265.00 ± 62.85 s). These findings suggest that Mangifera indica extracts exert neuroprotective effects by ameliorating ECT-induced cognitive and motor deficits, potentially through antioxidant and neurotransmitter-modulatory mechanisms. The results support their therapeutic potential as adjuncts in managing neurocognitive side effects of ECT.
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References
I. Akinmoladun, F. O., Komolafe, T. R., Farombi, O. E., & Oyedapo, O. O. (2022). Neuroprotective effects of medicinal plants in experimental models of epilepsy: A review. Frontiers in Pharmacology, 13, 903214.
https://doi.org/10.3389/fphar.2022.903214
II. Bauer, J., Henssler, J., & Heinz, A. (2019). Cognitive side effects of electroconvulsive therapy: An update. European Archives of Psychiatry and Clinical Neuroscience, 269(8), 913–924.
https://doi.org/10.1007/s00406-019-01053-3
III. Ogundele, O. M., et al. (2022). Pharmacological relevance of Mangifera indica in CNS disorders. Heliyon, 8(4), e09371. https://doi.org/10.1016/j.heliyon.2022.e09371
IV. Oyedapo, O. O., Akinmoladun, F. O., & Farombi, O. E. (2021). Phytochemical and pharmacological properties of Mangifera indica. Journal of Ethnopharmacology, 275, 113899.
https://doi.org/10.1016/j.jep.2021.113899
V. Porter, R. J., Douglas, K. M., & Knight, R. G. (2022). Effects of ECT on cognitive function in patients with depression. The Lancet Psychiatry, 9(5), 418–426.
https://doi.org/10.1016/S2215-0366(21)00507-4
VI. Qureshi, H. Y., Junaid, M., & Shah, A. M. (2022). Electroconvulsive therapy-induced behavioral and motor impairments in rats: Evidence for oxidative stress and inflammation. Brain Research Bulletin, 188, 41–49.
https://doi.org/10.1016/j.brainresbull.2022.05.001
VII. Rashid, M. H., Uddin, S. J., Afroz, R., et al. (2023). Phytochemical and pharmacological review of Mangifera indica: Emphasis on mangiferin. Biomedicine & Pharmacotherapy, 163, 114741.
https://doi.org/10.1016/j.biopha.2023.114741
VIII. Rocchi, L., Di Gregorio, F., & Rossi, S. (2023). Repeated electroconvulsive therapy increases neural excitability and oxidative stress in preclinical models. Brain Research Bulletin, 194, 165–174. https://doi.org/10.1016/j.brainresbull.2023.01.002
IX. Saha, S., Dutta, S., & Pal, P. B. (2021). Neuroprotective role of mangiferin in neurodegenerative disorders: A review. Neurochemistry International, 147, 105048.
https://doi.org/10.1016/j.neuint.2021.105048
X. Semkovska, M., & McLoughlin, D. M. (2010). Objective cognitive performance associated with electroconvulsive therapy for depression: A systematic review and meta-analysis. Biological Psychiatry, 68(6), 568–577.
https://doi.org/10.1016/j.biopsych.2010.06.009
XI. Uddin, M. S., Kabir, M. T., Rahman, M. S., et al. (2022). Natural products as neuroprotective agents: Current status and future perspectives. Frontiers in Aging Neuroscience, 14, 879908.