Exploring Moringa Concanensis: A Hidden Plant with Medicinal and Pharmacological Properties
Main Article Content
Abstract
The use of plant-based medicine has gained popularity as it is a natural method to combat present-day health problems. The Moringaceae family’s Moringa concanensis has been part of traditional Indian system of medicine for its healing abilities. This review through a light on the available scientific studies regarding Moringa concanensis, its phytochemicals and therapeutic applications. The plant contains numerous active compounds including flavonoids and phenolics along with tannins and alkaloids which exhibit strong biological effects. The plant demonstrates multiple pharmacological benefits that range from diabetes treatment to antioxidant, anti-inflammatory, anticonvulsant, anti-cancer, antimicrobial activities and immune support. The various reports demonstrated that Moringa concanensis have the potential for natural therapeutic agent development. The different plant parts such as leaves, seeds, bark, and roots contain unique medical qualities which show potential for specific therapeutic uses. However, the specific active constituents of this plant responsible for the therapeutic activities remains unclear today. Extensive work still needed to determine its therapeutic capacity, safety, and efficacy which have yet to be thoroughly studied.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
I. Amalraj S, Krupa J, Prabhu S, Murugan R, Raj MS, Gurav SS, et al. Exploring the phytochemical profile and therapeutic investigations on Moringa concanensis Nimmo pod husk extracts: An integrated in vitro and in silico approach. Biocatal Agric Biotechnol. 2024;58:103234.
II. Anitha TM, Shetty RG, Kumar PC, Rajasekharan PE. Evaluation of bioactive compounds in leaves of Moringa concanensis accessions. J Pharmacogn Phytochem. 2018:40–3.
III. Ayyanar M, Krupa J, Jenipher C, Amalraj S, Gurav SS. Phytochemical composition, in vitro antioxidant and antibacterial activity of Moringa concanensis Nimmo leaves. Vegetos. 2024;37(4):1377–88.
IV. Balamurugan V, Balakrishnan V. Evaluation of phytochemical, pharmacognostical and antimicrobial activity from the bark of Moringa concanensis Nimmo. Int J Curr Microbiol Appl Sci. 2013;2:117–25.
V. Balamurugan V, Balakrishnan V, Robinson JP, Ramakrishnan M. Anti-cancer and apoptosis-inducing effects of Moringa concanensis using HepG2 cell lines. Bangladesh J Pharmacol. 2014;9(4):604–9.
VI. Balakrishnan BB, Krishnasamy K, Choi KC. Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes via Akt signaling and STZ-induced diabetic rats. Biomed Pharmacother. 2018;103:719–28.
VII. Balakrishnan BB, Krishnasamy K. Evaluation of free radical screening and antioxidant potential of Moringa concanensis Nimmo—a medicinal plant used in Indian traditional medication system. Int J Pharm Pharm Sci. 2018;10(7):91–7.
VIII. Balakrishnan BB, Krishnasamy K, Mayakrishnan V, Selvaraj A. Moringa concanensis Nimmo extracts ameliorate hyperglycemia-mediated oxidative stress and upregulate PPARγ and GLUT4 gene expression. Biomed Pharmacother. 2019;112:108688.
IX. Christian S, Maitreya B. Seasonal analysis of phytochemicals in Moringa concanensis Nimmo ex Dalz. and Gibson from South Saurashtra zone, Junagadh - Gujarat, India. Int Assoc Biol Comput Dig. 2022;1(2):329.
X. Dey A, Bhattacharyya S, Kumar PT. Antioxidant activities of Moringa concanensis flowers (fresh and dried) grown in West Bengal. Int J Res Chem Environ. 2014;4(3):64–70.
XI. Dodiya T, Prajapati D, Patil V. A comparison of the pharmacognostic, nutritional, and phytochemical parameters of Moringa concanensis from three different geographical sources in India. In: The 4th International Electronic Conference on Nutrients: Plant-Based Diets – Health and Well-Being; 2024 Oct 11 [Internet]. MDPI; 2024.
XII. Jayabharathi M, Chitra M. Evaluation of anti-inflammatory, analgesic and antipyretic activity of Moringa concanensis Nimmo. J Chem Pharm Res. 2011;3(2):802–6.
XIII. Joy AE, Kunhikatta SB, Manikkoth S. Anti-convulsant activity of ethanolic extract of Moringa concanensis leaves in Swiss albino mice. Arch Med Health Sci. 2013;1(1):6–9.
XIV. Krupa J, Murugan R, Gangapriya P, Amalraj S, Gurav S, Arulraj MS, et al. Moringa concanensis Nimmo seed extracts as a potential source of bioactive molecules, antioxidants and enzyme inhibitors. J Food Meas Charact. 2022;16(5):3699–711.
XV. Mahmood KT, Mugal T, Haq IU. Moringa oleifera: a natural gift–A review. J Pharm Sci Res. 2010;2(11):775.
XVI. Metri S, Alam K, Thode K, Tirupati P, Mathew C. Comparative pharmacognostical and phytochemical analysis of Moringa oleifera and Moringa concanensis. Int J Pharm Phytopharmacol Res. 2024;14(3):1–8.
XVII. Mukherjee A, Hariprasad MG, Redhwan MA, Guha S. Evaluation of anti-arthritic activity of hydro-alcoholic root extract of Moringa concanensis in complete Freund’s adjuvant-induced arthritic rats. Res J Pharm Technol. 2024;17(8):3885–91.
XVIII. Patil V, Dodiya T. Extraction, isolation and structure elucidation of a bioactive constituent from chloroform extract of Moringa concanensis leaves. J Nat Remedies. 2022:673–82.
XIX. Patil V, Dodiya T. Pharmacognostic, phytochemical and nutritional profile of Moringa concanensis leaves. Int J Ayurvedic Med. 2022;13(1):55–60.
XX. Ragavendran PI, Sophia D, Raj CA, Gopikrishnan VK. Functional group analysis of various extracts of Aerva lanata (L.) by FTIR spectrum. Pharm Online Newsl. 2011;1:358–64.
XXI. Rao CV, Hussain MT, Verma AR, Kumar N, Vijayakumar M, Reddy GD. Evaluation of the analgesic and anti-inflammatory activity of Moringa concanensis tender fruits. Asian J Tradit Med. 2008;3:95–102.
XXII. Ravichandran V, Arunachalam G, Subramanian N, Suresh B. Pharmacognostical and phytochemical investigations of Moringa concanensis (Moringaceae) an ethno medicine of Nilgiris. J Pharmacogn Phytother. 2009;1:76–81.
XXIII. Santhanam R, Karunakaran T, Sowndhararajan K, et al. Photoprotective potential, cytotoxicity, and UPLC-QTOF/MS analysis on bioactive solvent fractions of Moringa concanensis Nimmo bark. Evid Based Complement Alternat Med. 2022;2022:3781189.
XXIV. Santhi K, Sengottuvel R. Qualitative and quantitative phytochemical analysis of Moringa concanensis Nimmo. Int J Curr Microbiol Appl Sci. 2016;5(1):633–40.
XXV. Shantilal S, Vaghela JS. Evaluation of immunomodulatory activity of ethanolic extracts of Moringa concanensis Nimmo in mice. J Adv Sci Res. 2020;11(2):187–94.
XXVI. Singh S, Singh DP, Singh DK, Maurya A, Maurya P, Saini A. Pharmacognostic study of Moringa concanensis Nimmo bark. Int J Res Dev Pharm Life Sci. 2013;4(2):538–44.
XXVII. Singh A, Mishra JN, Singh SK. Anti-Diabetic Activity of ethanolic extract of Moringa concanensis Nimmo leaf in Diabetic Rats Induced by Alloxan. SGVU J Pharm Res Educ. 2021;6(2):635-641.
XXVIII. Vijayakumar S, Bhuvaneshwari V, Sumathi A. Antioxidant and anticancer potential of methanolic leaf extract of Moringa concanensis Nimmo
against MCF-7. Int J Pharmacogn Phytochem Res. 2017;9(6):750–4.
XXIX. Vijayarajan M, Pandian MR. Cytotoxicity of methanol and acetone root bark extracts of Moringa concanensis against A549, Hep-G2, and HT-29 cell lines. J Acad Ind Res. 2016;5:45–9.
XXX. Yadav BS, Trilochana Y, Kumari K, Singh S, Sachan AK. Evaluation of antibacterial and antifungal activity of Moringa concanensis. Int J Pharm Sci Nanotechnol. 2021;14(4):5566–70.