Anti-Gastric Ulcer Activity of Red Cabbage Ethanol Extract (Brassica Oleracea Var. Capitata L.)

Abstract

Gastric ulcer is a disease characterized by damage to the gastric mucosal lining. Gastric ulcers can be caused by the use of non-steroidal anti-inflammatory drugs, Helicobacter pylori bacterial infection, smoking, and stress. The use of drugs tends to have negative effects on the body and safer alternative drugs from natural ingredients are needed. Therefore, this study aims to determine the anti-gastric ulcer activity of red cabbage (Brassica oleracea var. Capitata L.) ethanol extract on the stomach of mice induced by aspirin and determine the best dose that provides protection. This research method includes sample preparation, extraction by maceration. Furthermore, the flavonoid test uses a qualitative staining test method. While the anti-gastric ulcer test uses a laboratory experimental method with a Posttest Only Control Group Design designs. A total of 25 male mice were divided into 5 groups with 5 mice in each group including cabbage extract at a dose of 21 mg/Kg BW of mice, cabbage extract at a dose of 42 mg/Kg BW of mice, cabbage extract at a dose of 84 mg/Kg BW of mice, a comparison of cimetidine 0.52 mg/Kg BW of mice, and the control was only given distilled water. The results of the study showed that red cabbage extract contains flavonoid compounds and can reduce the average number and severity of gastric ulcers in mice with an optimum dose of 84 mg/kg BW.